PPIRE00007

Target Protein Information
Protein_Name Substance-P receptor
Protein_Sequence MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names TACR1
UniProt_ID P25103
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Bledoisin
Peptide_Sequence XQHSKDAFILGM
Peptide_Length 12
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(N)=O)NC(=O)CN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1303.50
Aliphatic_Index 73.33333
Aromaticity 0.08333
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 0.08904
Isoelectric_Point 7.54935
Hydrogen_Bond_Acceptors 19
Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 538.74000
X_logP_energy -5.07090
Interaction Information
Affinity KD=15 uM
Affinity_Assay Radioligand Binding Assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Agonist and antagonist binding to tachykinin peptide NK-2 receptors.
Release_Year 1988
PMID 2838713
DOI 10.1016/0024-3205(88)90246-9