Welcome to PPIKB
PPIKB: A Structure–Activity Knowledge Base and Analysis Platform for Peptide Ligand–Protein Interactions
Example: Name: TACR1; Sequence: PCKARIfPYGGCR; UniProt ID: P00760
Target protein
>2000
Total entries
40347
Structure
18005
GPCR protein
Plasma membrane
Bacteria
Cyclic peptide
More classification
About PPIKB
PPIKB is a Structure–Activity Knowledge Base and Analysis Platform for Peptide Ligand–Protein Interactions. The main data include affinity, sequence, structure, references, physicochemical information of peptides, information of proteins, etc. The data mainly comes from research papers and patents. To facilitate the use of researchers, PPIKB provides a variety of functions for data retrieval and analysis, including various search settings. In addition, it also integrates Foldseek, BLAST, SMILES Similarity to analyze the data.
PPIKB is developed by Professor Duan Hongliang of Macau Polytechnic University. The open source agreement is CCBY 4.0. Please use our database in accordance with the CCBY 4.0 agreement. If you have any questions, comments or requests, please contact us via email hduan@mpu.edu.mo or the Submit page of the website. We sincerely thank you for any comments.
The current data source of PPIKB is as of May 2025, We will continue to iterate and update, please see Website update log for the specific update log.
November 30,2025
July 28, 2025
598 new protein-peptide affinity entries added from published patent collections.
June 23, 2025
SMILES similarity upgraded to Structure (SMILES) similarity, which can be searched based on chemical structure drawing.
