June 16,2026

• Database-wide verification: all affinity and structure entries were re-checked against their original literature and patent sources. Position annotations in modified-peptide entries were corrected, and records whose non-standard residues could not be resolved were removed. The current verified release contains 21,845 affinity measurements and 18,005 structural complexes.At the same time, we removed the data from retracted research articles.

April 24,2026

• We've added peptide drug entries and a peptide drug search function. Welcome to use it!

January 21,2026

• Added new affinity data from 10 published patents.

November 30,2025

• Similarity search has been updated with a new algorithm.

October 28,2025

• PHP version upgrade

September 19,2025

• The website's front-end interaction has been optimized.

July 28,2025

• 598 new protein-peptide affinity entries added from published patent collections.

June 23,2025

• SMILES similarity upgraded to Structure (SMILES) similarity, which can be searched based on chemical structure drawing.

May 21,2025

• Cleaned and corrected some erroneous data.

April 21,2025

• Updated affinity and structure entries.

March 23,2025

• Updated affinity and structure entries.

February 19,2025

• Some dulplicate sequences were integrated and entries in general dataset have distinct sequences.

January 4,2025

• Fixed the website bug and improved the usability of PPIKB.

November 29,2024

• Data update, updated affinity data

October 30,2024

• Integrated Mol* Viewer for web display and editing of compound structures

September 12,2024

• Database updated，Updated structural information of the complex!

August 06,2024

• FTP software is provided.

July 03,2024

• Database updated!

June 15,2024

• Several analysis tools (BLAST, Foldseek, SMILES Similarity, Ketcher Structure Editor) are integrated into PPIKB

January 20,2024

• PPIKB is officially established ! Welcome to comment ad suggest!!!