PPIRE00034

Target Protein Information
Protein_Name Gastrin-releasing peptide receptor
Protein_Sequence MAPNNCSHLNLDVDPFLSCNDTFNQSLSPPKMDNWFHPGFIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLAIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLMNRSHSTGRSTTCMTSFKSTNPSATFSLINRNICHEGYV
Organism_Source Mus musculus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Grpr
UniProt_ID P21729
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Compound 1
Peptide_Sequence XQRLGNQWAVGH
Peptide_Length 12
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)CN)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O)C(C)C
Chemical_Modification X1=Pyroglutamic acid, CH2NH bond between W8 and A9
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1322.45
Aliphatic_Index 65.00000
Aromaticity 0.08333
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 1.08889
Isoelectric_Point 10.55176
Hydrogen_Bond_Acceptors 18
Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 619.06000
X_logP_energy -7.29323
Interaction Information
Affinity IC50=7.6 nM
Affinity_Assay Radioligand Binding Assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title A gastrin-releasing peptide antagonist containing A psi (CH2O)amide bond surrogate.
Release_Year 1989
PMID 2590213
DOI 10.1016/0006-291x(89)91041-3