PPIRE00169

Target Protein Information
Protein_Name Melanocyte-stimulating hormone receptor
Protein_Sequence MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names MC1R
UniProt_ID Q01726
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name aMSH
Peptide_Sequence SYSMEHFRWGKPV
Peptide_Length 13
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1623.85
Aliphatic_Index 22.30769
Aromaticity 0.23077
Average_Rotatable_Bonds 3.76923
Charge_at_pH_7 1.08952
Isoelectric_Point 9.29976
Hydrogen_Bond_Acceptors 22
Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 634.11000
X_logP_energy -4.11493
Interaction Information
Affinity IC50=832000 nM
Affinity_Assay Ligand competition binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Potent and selective agonists of alpha-melanotropin (alphaMSH)action at human melanocortin receptor 5; linear analogs of alpha-melanotropin.
Release_Year 2007
PMID 17376561
DOI 10.1016/j.peptides.2007.02.011