PPIRE00172

Target Protein Information
Protein_Name Melanocyte-stimulating hormone receptor
Protein_Sequence MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names MC1R
UniProt_ID Q01726
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SHU9119
Peptide_Sequence XDHXRWK
Peptide_Length 7
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(=O)O)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification X1=Norleucine, X4=2'-Naphthylalanine
Cyclization_Method D2<>K7; Main chain cyclization; Amide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 854.92
Aliphatic_Index 0.00000
Aromaticity 0.14286
Average_Rotatable_Bonds 3.85714
Charge_at_pH_7 1.08904
Isoelectric_Point 9.69702
Hydrogen_Bond_Acceptors 12
Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 407.61000
X_logP_energy -3.87333
Interaction Information
Affinity IC50=5.25 nM
Affinity_Assay Ligand competition binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Potent and selective agonists of alpha-melanotropin (alphaMSH)action at human melanocortin receptor 5; linear analogs of alpha-melanotropin.
Release_Year 2007
PMID 17376561
DOI 10.1016/j.peptides.2007.02.011