PPIRE00173

Target Protein Information
Protein_Name Melanocyte-stimulating hormone receptor
Protein_Sequence MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names MC1R
UniProt_ID Q01726
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name (Nle4,D-Nal7)-aMSH [NDN-aMSH]
Peptide_Sequence SYSXEHXRWGKPV
Peptide_Length 13
Peptide_SMILES CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)O
Chemical_Modification X4=Norleucine, X7=2'-Naphthylalanine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1459.58
Aliphatic_Index 22.30769
Aromaticity 0.15385
Average_Rotatable_Bonds 3.38462
Charge_at_pH_7 1.08952
Isoelectric_Point 9.29976
Hydrogen_Bond_Acceptors 21
Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 634.11000
X_logP_energy -6.84793
Interaction Information
Affinity IC50=2690 nM
Affinity_Assay Ligand competition binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Potent and selective agonists of alpha-melanotropin (alphaMSH)action at human melanocortin receptor 5; linear analogs of alpha-melanotropin.
Release_Year 2007
PMID 17376561
DOI 10.1016/j.peptides.2007.02.011