PPIRE00222
Target Protein Information
| Protein_Name | Melanocortin receptor 5 |
|---|---|
| Protein_Sequence | MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD |
| Organism_Source | Homo sapiens |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | MC5R |
| UniProt_ID | P33032 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | (Oic6,dBip7,Pip8)-MTII [OBP-MTII] |
|---|---|
| Peptide_Sequence | XDXXXWK |
| Peptide_Length | 7 |
| Peptide_SMILES | NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)CN)C(=O)O |
| Chemical_Modification | X1=Norleucine, X3=Octahydroindole-2-carboxylic acid, X4=D-4,4'-Biphenylalanine, X5=Pipecolic acid |
| Cyclization_Method | D2<>K7; Main chain cyclization; Amide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 675.70 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.14286 |
| Average_Rotatable_Bonds | 3.00000 |
| Charge_at_pH_7 | -0.00186 |
| Isoelectric_Point | 6.33737 |
|---|---|
| Hydrogen_Bond_Acceptors | 10 |
| Hydrogen_Bond_Donors | 11 |
| Topological_Polar_Surface_Area | 317.03000 |
| X_logP_energy | -3.83960 |
Interaction Information
| Affinity | IC50=3710000 nM |
|---|---|
| Affinity_Assay | Ligand competition binding assay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Potent and selective agonists of alpha-melanotropin (alphaMSH)action at human melanocortin receptor 5; linear analogs of alpha-melanotropin. |
| Release_Year | 2007 |
| PMID | 17376561 |
| DOI | 10.1016/j.peptides.2007.02.011 |