PPIRE00331

Target Protein Information
Protein_Name High affinity immunoglobulin epsilon receptor subunit gamma
Protein_Sequence MIPAVILFLLLLVEEAAALGEPQLCYILDAILFLYGIVLTLLYCRLKIQVRKADIASREKSDAVYTGLNTRNQETYETLKHEKPPQ
Organism_Source Rattus norvegicus
Functional_Classification Receptor
Cellular_Localization Plasma membrane
Gene_Names Fcer1g
UniProt_ID P20411
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name [Ala12]MCD
Peptide_Sequence IKCNCKRHVIKAHICKRICKGKN
Peptide_Length 23
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)C(C)C
Chemical_Modification None
Cyclization_Method C3<->C15; C5<->C19; Side chain cyclization; Disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2694.38
Aliphatic_Index 84.78261
Aromaticity 0.00000
Average_Rotatable_Bonds 4.26087
Charge_at_pH_7 7.93013
Isoelectric_Point 10.79644
Hydrogen_Bond_Acceptors 40
Hydrogen_Bond_Donors 44
Topological_Polar_Surface_Area 1126.98000
X_logP_energy -10.74226
Interaction Information
Affinity IC50=2000 nM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title [Ala12]MCD peptide: a lead peptide to inhibitors of immunoglobulin E binding to mast cell receptors.
Release_Year 2008
PMID 16083440
DOI 10.1111/j.1399-3011.2005.00281.x