PPIRE01970

Target Protein Information
Protein_Name Cadherin-2
Protein_Sequence MCRIAGAPRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLPKDVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLTAEQAKFLIYAQDKETQEKWQVAVNLSREPTLTEEPMKEPHEIEEIVFPRQLAKHSGALQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTPAWNAAYRISGGDPTGRFAILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTINRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYGGGDD
Organism_Source Mus musculus
Functional_Classification Receptor
Cellular_Localization Plasma membrane
Gene_Names Cdh2
UniProt_ID P15116
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name NCBP-4
Peptide_Sequence KXXFXFCXFYYKXXK
Peptide_Length 15
Peptide_SMILES NCCCC[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CCCCN)C(=O)O
Chemical_Modification X2=3-(2-naphthyl)-L-alanine; X3=4-aminopiperidine-4-carboxylic?acid; X5=cyclopentylglycine; X8=trans-4-hydroxyproline; X13=trans-4-hydroxyproline; X14=penicillamine
Cyclization_Method C7<->X14, side chain cyclization, disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1615.87
Aliphatic_Index 0.00000
Aromaticity 0.33333
Average_Rotatable_Bonds 3.46667
Charge_at_pH_7 2.93342
Isoelectric_Point 9.88818
Hydrogen_Bond_Acceptors 22
Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 589.24000
X_logP_energy -4.08460
Interaction Information
Affinity KD=29 nM
Affinity_Assay Bio-Layer Interferometry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Affinity selection-mass spectrometry with linearizable macrocyclic peptide libraries.
Release_Year 2025
PMID 40106557
DOI 10.1126/sciadv.adr1018