PPIRE10542

Target Protein Information
Protein_Name Growth factor receptor-bound protein 2
Protein_Sequence MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Organism_Source Homo sapiens
Functional_Classification SH3 domains
Cellular_Localization Cytoplasm
Gene_Names GRB2
UniProt_ID P62993
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name GPPPQVPSRPNR
Peptide_Sequence GPPPQVPSRPNR
Peptide_Length 12
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1301.47
Aliphatic_Index 24.16667
Aromaticity 0.00000
Average_Rotatable_Bonds 2.75000
Charge_at_pH_7 1.99798
Isoelectric_Point 12.50011
Hydrogen_Bond_Acceptors 18
Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 569.68000
X_logP_energy -7.79076
Interaction Information
Affinity KD=300 mM
Affinity_Assay fluorescence spectroscopy
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Molecular and cellular analysis of Grb2 SH3 domain mutants: interaction with Sos and dynamin.
Release_Year 1999
PMID 10395825
DOI 10.1006/jmbi.1999.2899