PPIRE13141

Target Protein Information
Protein_Name Histone-lysine N-methyltransferase SETD7
Protein_Sequence MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK
Organism_Source Homo sapiens
Functional_Classification methyltransferases
Cellular_Localization Nucleus
Gene_Names SETD7
UniProt_ID Q8WTS6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3 20-mer peptide
Peptide_Sequence ARTKQTARKSTGGKAPRKQY
Peptide_Length 20
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2233.56
Aliphatic_Index 15.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 3.90000
Charge_at_pH_7 6.99594
Isoelectric_Point 12.28363
Hydrogen_Bond_Acceptors 35
Hydrogen_Bond_Donors 40
Topological_Polar_Surface_Area 1084.54000
X_logP_energy -15.64199
Interaction Information
Affinity KD=2.4 uM
Affinity_Assay fluorometric competition assay
PDB_ID 1O9S
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Regulation of p53 activity through lysine methylation.
Release_Year 2004
PMID 15525938
DOI 10.1038/nature03117