PPIRE13224

Target Protein Information
Protein_Name Harmonin
Protein_Sequence MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF
Organism_Source Homo sapiens
Functional_Classification scaffold protein
Cellular_Localization Cytoplasm
Gene_Names USH1C
UniProt_ID Q9Y6N9
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Cad23 internal peptide
Peptide_Sequence KPDDDRYLRAAIQEYDNIAK
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2394.63
Aliphatic_Index 73.50000
Aromaticity 0.10000
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 -1.00075
Isoelectric_Point 4.59810
Hydrogen_Bond_Acceptors 34
Hydrogen_Bond_Donors 37
Topological_Polar_Surface_Area 1096.41000
X_logP_energy -10.10066
Interaction Information
Affinity KD=25 uM
Affinity_Assay fluorescence titration
PDB_ID 2KBR
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23.
Release_Year 2009
PMID 19297620
DOI 10.1073/pnas.0901819106