PPIRE13255

Target Protein Information
Protein_Name Heat shock 70 kDa protein 1A
Protein_Sequence MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
Organism_Source Homo sapiens
Functional_Classification molecular chaperones
Cellular_Localization Cytoplasm
Gene_Names HSPA1A
UniProt_ID P0DMV8
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CMV-L1-J1
Peptide_Sequence NLVPMVATVGSGNLLRLTGW
Peptide_Length 20
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(N)=O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2098.49
Aliphatic_Index 126.50000
Aromaticity 0.05000
Average_Rotatable_Bonds 3.25000
Charge_at_pH_7 0.99798
Isoelectric_Point 10.55000
Hydrogen_Bond_Acceptors 28
Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 831.99000
X_logP_energy -7.57273
Interaction Information
Affinity KD=0.9 uM
Affinity_Assay fluorescence competition assay
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title High-affinity interactions between peptides and heat shock protein 70 augment CD8+ T lymphocyte immune responses.
Release_Year 2006
PMID 16818758
DOI 10.4049/jimmunol.177.2.1017