PPIRE13694

Target Protein Information
Protein_Name Calmodulin-1
Protein_Sequence MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Organism_Source Homo sapiens
Functional_Classification EF-hand calcium-binding proteins
Cellular_Localization Cytoplasm
Gene_Names CALM1
UniProt_ID P0DP23
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Fl-NR1C1p
Peptide_Sequence KKKATFRAITSTLASSFKRRRSSK
Peptide_Length 24
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Fluorescein
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2756.25
Aliphatic_Index 45.00000
Aromaticity 0.08333
Average_Rotatable_Bonds 4.12500
Charge_at_pH_7 8.99650
Isoelectric_Point 12.99568
Hydrogen_Bond_Acceptors 42
Hydrogen_Bond_Donors 50
Topological_Polar_Surface_Area 1272.16000
X_logP_energy -17.01202
Interaction Information
Affinity KD=2 nM
Affinity_Assay fluorescence anisotropy
PDB_ID 2HQW
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The NMDA receptor NR1 C1 region bound to calmodulin: structural insights into functional differences between homologous domains.
Release_Year 2007
PMID 18073110
DOI 10.1016/j.str.2007.10.012