PPIRE14013
Target Protein Information
| Protein_Name | Fragile X messenger ribonucleoprotein 1 |
|---|---|
| Protein_Sequence | MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKENSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRGHGRRGPGYTSGTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGGRGQGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQNTSSEGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP |
| Organism_Source | Homo sapiens |
| Functional_Classification | RGG-box proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | FMR1 |
| UniProt_ID | Q06787 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | FMRP RGG peptide R8K |
|---|---|
| Peptide_Sequence | GPRRGDGKRRGGGGRGQGGRGRGGGFKG |
| Peptide_Length | 28 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 2710.97 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.03571 |
| Average_Rotatable_Bonds | 3.46429 |
| Charge_at_pH_7 | 7.99782 |
| Isoelectric_Point | 12.90273 |
|---|---|
| Hydrogen_Bond_Acceptors | 40 |
| Hydrogen_Bond_Donors | 53 |
| Topological_Polar_Surface_Area | 1405.96000 |
| X_logP_energy | -24.45111 |
Interaction Information
| Affinity | KD=175 nM |
|---|---|
| Affinity_Assay | filter-binding assay |
| PDB_ID | 2LA5 |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction. |
| Release_Year | 2011 |
| PMID | 21642970 |
| DOI | 10.1038/nsmb.2064 |