PPIRE14966

Target Protein Information
Protein_Name CHRNA7-FAM7A fusion protein
Protein_Sequence MQKYCIYQHFQFQLLIQHLWIAANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Organism_Source Homo sapiens
Functional_Classification ligand-gated ion channel
Cellular_Localization Plasma membrane
Gene_Names CHRFAM7A
UniProt_ID Q494W8
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MARCKS ED peptide
Peptide_Sequence KKKKKRFSFKKSFKLSGFSFKKNK
Peptide_Length 24
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Myristoylation
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2952.63
Aliphatic_Index 16.25000
Aromaticity 0.20833
Average_Rotatable_Bonds 4.70833
Charge_at_pH_7 11.99474
Isoelectric_Point 12.26265
Hydrogen_Bond_Acceptors 42
Hydrogen_Bond_Donors 44
Topological_Polar_Surface_Area 1204.75000
X_logP_energy -10.03343
Interaction Information
Affinity IC50=16 nM
Affinity_Assay two-electrode voltage-clamp dose-response
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide.
Release_Year 2008
PMID 18812491
DOI 10.1124/jpet.108.144758