PPIRE15095

Target Protein Information
Protein_Name Protein kinase C and casein kinase substrate in neurons protein 3
Protein_Sequence MAPEEDAGGEALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHRPVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECVGA
Organism_Source Homo sapiens
Functional_Classification SH3 domain proteins
Cellular_Localization Cytoplasm
Gene_Names PACSIN3
UniProt_ID Q9UKS6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TRPV4-PRR
Peptide_Sequence TKGPAPNPPPVLKVW
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1600.92
Aliphatic_Index 71.33333
Aromaticity 0.06667
Average_Rotatable_Bonds 2.73333
Charge_at_pH_7 1.99739
Isoelectric_Point 10.80538
Hydrogen_Bond_Acceptors 20
Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 557.92000
X_logP_energy -3.03590
Interaction Information
Affinity KD=68.6 uM
Affinity_Assay NMR chemical shift perturbation
PDB_ID 6F55
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Structural Basis of TRPV4?N Terminus Interaction with Syndapin/PACSIN1-3 and PIP2.
Release_Year 2018
PMID 30244966
DOI 10.1016/j.str.2018.08.002