PPIRE16064

Target Protein Information
Protein_Name H-2 class II histocompatibility antigen A-K alpha chain/H-2 class II histocompatibility antigen A-K beta chain
Protein_Sequence MPRSRALILGVLALTTMLSLCGGEDDIEADHVGSYGITVYQSPGDIGQYTFEFDGDELFYVDLDKKETVWMLPEFAQLRRFEPQGGLQNIATGKHNLEILTKRSNSTPATNEAPQATVFPKSPVLLGQPNTLICFVDNIFPPVINITWLRNSKSVTDGVYETSFFVNRDYSFHKLSYLTFIPSDDDIYDCKVEHWGLEEPVLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTIFIIQGLRSGGTSRHPGPL/MALQIPSLLLLAAVVVLTVLSSPGTEGGNSERHFVHQFQPFCYFTNGTQRIRLVIRYIYNREEYVRFDSDVGEYRAVTELGRPDAEYWNKQYLERTRAELDTVCRHNYEKTETPTSLRRLEQPSVVISLSRTEALNHHNTLVCSVTDFYPAKIKVRWFRNGQEETVGVSSTQLIRNGDWTFQVLVMLEMTPRRGEVYTCHVEHPSLKSPITVEWRAQSESARSKMLSGIGGCVLGVIFLGLGLFIRHRSQKGPRGPPPAGLLQ
Organism_Source Mus musculus/Mus musculus
Functional_Classification MHC class 2
Cellular_Localization Plasma membrane
Gene_Names H2-Aa/H2-Ab1
UniProt_ID P01910/P06343
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pHEL48-61
Peptide_Sequence DGSTDYGILQINSR
Peptide_Length 14
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1538.63
Aliphatic_Index 83.57143
Aromaticity 0.07143
Average_Rotatable_Bonds 3.64286
Charge_at_pH_7 -1.00198
Isoelectric_Point 4.10925
Hydrogen_Bond_Acceptors 24
Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 745.22000
X_logP_energy -10.23093
Interaction Information
Affinity KD=1.4 mM
Affinity_Assay Competition binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Single-Molecule Motions of MHC Class II Rely on Bound Peptides
Release_Year 2015
PMID 25606683
DOI 10.1016/j.bpj.2014.12.004