PPIRE16363

Target Protein Information
Protein_Name Ig gamma-2A chain C region A allele
Protein_Sequence AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK
Organism_Source Mus musculus
Functional_Classification antibody
Cellular_Localization Extracellular
Gene_Names Ighg
UniProt_ID P01863
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name GXTDTaNNL
Peptide_Sequence GXTDTaNNL
Peptide_Length 9
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)CNC(=O)CN)[C@@H](C)O)[C@@H](C)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 861.86
Aliphatic_Index 54.44444
Aromaticity 0.00000
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -1.00157
Isoelectric_Point 3.74999
Hydrogen_Bond_Acceptors 15
Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 460.06000
X_logP_energy -8.40740
Interaction Information
Affinity KD=500 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID 1MPA
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Exploring computational lead optimisation with affinity constants obtained by surface plasmon resonance for the interaction of PorA epitope peptides with antibody against Neisseria meningitidis
Release_Year 2001
PMID 11786227
DOI 10.1016/S0304-4165(01)00215-X