PPIRE16390
Target Protein Information
| Protein_Name | Beta-2-microglobulin |
|---|---|
| Protein_Sequence | MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM |
| Organism_Source | Homo sapiens |
| Functional_Classification | MHC class1 |
| Cellular_Localization | Extracellular |
| Gene_Names | B2M |
| UniProt_ID | P61769 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | pep381 |
|---|---|
| Peptide_Sequence | CRRYSHQHYRHC |
| Peptide_Length | 12 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain-side chain cyclization; C1<-->C12; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 1645.84 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.16667 |
| Average_Rotatable_Bonds | 4.25000 |
| Charge_at_pH_7 | 3.14505 |
| Isoelectric_Point | 9.42114 |
|---|---|
| Hydrogen_Bond_Acceptors | 25 |
| Hydrogen_Bond_Donors | 31 |
| Topological_Polar_Surface_Area | 758.94000 |
| X_logP_energy | -8.56769 |
Interaction Information
| Affinity | KD=38 uM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Computational Evolution of Beta-2-Microglobulin Binding Peptides for Nanopatterned Surface Sensors |
| Release_Year | 2021 |
| PMID | 33467468 |
| DOI | 10.3390/ijms22020812 |