PPIRE16462

Target Protein Information
Protein_Name Growth factor receptor-bound protein 7
Protein_Sequence MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
Organism_Source Homo sapiens
Functional_Classification adapter proteins
Cellular_Localization Cytoplasm
Gene_Names GRB7
UniProt_ID Q14451
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name G7-18NATE
Peptide_Sequence WFEGYDNTFPC
Peptide_Length 11
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method Main chain-side chain cyclization; N1<-->C11; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1378.48
Aliphatic_Index 0.00000
Aromaticity 0.36364
Average_Rotatable_Bonds 3.36364
Charge_at_pH_7 -2.06262
Isoelectric_Point 3.55007
Hydrogen_Bond_Acceptors 18
Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 519.47000
X_logP_energy -2.93290
Interaction Information
Affinity KD=7.98 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID 3PQZ
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Insight into the Selectivity of the G7-18NATE Inhibitor Peptide for the Grb7-SH2 Domain Target
Release_Year 2017
PMID 29018805
DOI 10.3389/fmolb.2017.00064