PPIRE16552

Target Protein Information
Protein_Name HSPA8-interacting micropeptide miPEP155
Protein_Sequence MEMALMVAQTRKGKSVV
Organism_Source Homo sapiens
Functional_Classification ATPases
Cellular_Localization Cytoplasm
Gene_Names MIR155HG
UniProt_ID C0HMA1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide13
Peptide_Sequence GLEDIPLETKTLEEGGTFAEF
Peptide_Length 21
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2296.51
Aliphatic_Index 79.04762
Aromaticity 0.09524
Average_Rotatable_Bonds 3.61905
Charge_at_pH_7 -4.99299
Isoelectric_Point 3.58893
Hydrogen_Bond_Acceptors 32
Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 947.04000
X_logP_energy -7.74550
Interaction Information
Affinity EC50=37 uM
Affinity_Assay Colorimetric binding assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth
Release_Year 2009
PMID 19800331
DOI 10.1016/j.febslet.2009.09.047