PPIRE16629
Target Protein Information
| Protein_Name | Ras-related protein Rab-6A |
|---|---|
| Protein_Sequence | MSTGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC |
| Organism_Source | Homo sapiens |
| Functional_Classification | GTPases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | RAB6A |
| UniProt_ID | P20340 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Rab6IP1(900-916) |
|---|---|
| Peptide_Sequence | DEKEQFLYHLLSFNAV |
| Peptide_Length | 16 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 1953.18 |
|---|---|
| Aliphatic_Index | 97.50000 |
| Aromaticity | 0.18750 |
| Average_Rotatable_Bonds | 4.00000 |
| Charge_at_pH_7 | -1.90826 |
| Isoelectric_Point | 4.42146 |
|---|---|
| Hydrogen_Bond_Acceptors | 26 |
| Hydrogen_Bond_Donors | 26 |
| Topological_Polar_Surface_Area | 793.06000 |
| X_logP_energy | -4.64950 |
Interaction Information
| Affinity | KD=20 uM |
|---|---|
| Affinity_Assay | binding assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | HOPPI-NMR: Hot-Peptide-Based Screening Assay for Inhibitors of Protein-1rotein Interactions by NMR |
| Release_Year | 2020 |
| PMID | 32435424 |
| DOI | 10.1021/acsmedchemlett.9b00620 |