PPIRE16805
Target Protein Information
| Protein_Name | Islet amyloid polypeptide |
|---|---|
| Protein_Sequence | MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL |
| Organism_Source | Homo sapiens |
| Functional_Classification | amyloid peptides |
| Cellular_Localization | Extracellular |
| Gene_Names | IAPP |
| UniProt_ID | P10997 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | LPFFD |
|---|---|
| Peptide_Sequence | LPFFD |
| Peptide_Length | 5 |
| Peptide_SMILES | CC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 637.73 |
|---|---|
| Aliphatic_Index | 78.00000 |
| Aromaticity | 0.40000 |
| Average_Rotatable_Bonds | 3.20000 |
| Charge_at_pH_7 | -1.00157 |
| Isoelectric_Point | 3.74999 |
|---|---|
| Hydrogen_Bond_Acceptors | 7 |
| Hydrogen_Bond_Donors | 6 |
| Topological_Polar_Surface_Area | 208.23000 |
| X_logP_energy | 0.84990 |
Interaction Information
| Affinity | KD=173 uM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | SPRi determination of inter-peptide interaction by using 3D supramolecular co-assembly polyrotaxane film |
| Release_Year | 2015 |
| PMID | 25437373 |
| DOI | 10.1016/j.bios.2014.11.025 |