PPIRE16835
Target Protein Information
| Protein_Name | Lymphocyte function-associated antigen 3 |
|---|---|
| Protein_Sequence | MVAGSDAGRALGVLSVVCLLHCFGFISCFSQQIYGVVYGNVTFHVPSNVPLKEVLWKKQKDKVAELENSEFRAFSSFKNRVYLDTVSGSLTIYNLTSSDEDEYEMESPNITDTMKFFLYVLESLPSPTLTCALTNGSIEVQCMIPEHYNSHRGLIMYSWDCPMEQCKRNSTSIYFKMENDLPQKIQCTLSNPLFNTTSSIILTTCIPSSGHSRHRYALIPIPLAVITTCIVLYMNGILKCDRKPDRTNSN |
| Organism_Source | Homo sapiens |
| Functional_Classification | cell adhesion molecules |
| Cellular_Localization | Plasma membrane |
| Gene_Names | CD58 |
| UniProt_ID | P19256 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | SFTI-a1 |
|---|---|
| Peptide_Sequence | CKSAPPSCAYDGDD |
| Peptide_Length | 14 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Multi-point cyclization; C1<-->C8; disulfide bond; C1<-->D14; amide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1428.51 |
|---|---|
| Aliphatic_Index | 14.28571 |
| Aromaticity | 0.07143 |
| Average_Rotatable_Bonds | 2.92857 |
| Charge_at_pH_7 | -2.12577 |
| Isoelectric_Point | 3.82608 |
|---|---|
| Hydrogen_Bond_Acceptors | 24 |
| Hydrogen_Bond_Donors | 22 |
| Topological_Polar_Surface_Area | 622.65000 |
| X_logP_energy | -9.27010 |
Interaction Information
| Affinity | IC50=23.34 nM |
|---|---|
| Affinity_Assay | lymphocyte cell adhesion assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Modulation of costimulatory signal from CD2-CD58 proteins by a grafted peptide |
| Release_Year | 2018 |
| PMID | 32946175 |
| DOI | 10.1111/CBDD.13797 |