PPIRE17057

Target Protein Information
Protein_Name HLA class II histocompatibility antigen DR alpha chain
Protein_Sequence MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIKGLRKSNAAERRGPL
Organism_Source Homo sapiens
Functional_Classification major histocompatibility complex class 2
Cellular_Localization Plasma membrane
Gene_Names HLA-DRA
UniProt_ID P01903
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name K65A
Peptide_Sequence VTELGRPDAEYWNSQADL
Peptide_Length 18
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification biotin
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2064.20
Aliphatic_Index 70.55556
Aromaticity 0.11111
Average_Rotatable_Bonds 3.55556
Charge_at_pH_7 -2.99843
Isoelectric_Point 3.73792
Hydrogen_Bond_Acceptors 29
Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 922.99000
X_logP_energy -9.30593
Interaction Information
Affinity KD=1.22 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Induced Fit of an Epitope Peptide to a Monoclonal Antibody Probed with a Novel Parallel Surface Plasmon Resonance Assay
Release_Year 2004
PMID 15556932
DOI 10.1074/jbc.M410687200