PPIRE17113
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | MADDRKDEAKAPHWTSAQLTEASAQPHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSTDRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQPKDQPPALPLAAEETANLPPSPPPSPASEQTVPVEEEEETLESPVAEEEKPATLPEKECGAAKVSDQPKGLSEGQVESSAEAQVVPADSASAGAPQEKSVKEVTVTEVSPEVKTPSSAGEGLLTASKMEFHDQQELTPSPAEPLDKKEKEPETESKPGEDLKHAALVSELETTKTSPDKKDIQGTEEEKAPPTLFGHTLGASLEDTKPKTEPSLVVPDIGLPAEPTAAKEQKDWFIQMPTEAKKDEWGLVAPVSPGPLTPMKEKDVLEDIPKWEGKQFDSPMPSPFQGGSFTLPFDISKHEIVAAAASFAPALLQPDDQKSLEETGSPATAKDSSKVEEPQKDQPDKIAEAPASEAVAAPKDAHVSIVEECVPEKVSGEEKGMIKEESVQIKETPTLSEQESTLAEKEPHLKLEEKPTISDKEAMPKESEPPKLIDEETNIIQPSTEHTYSKKKKK |
| Organism_Source | Bos taurus |
| Functional_Classification | microtubule associated proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | MAP2 |
| UniProt_ID | Q0IIA8 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | a(430-441) |
|---|---|
| Peptide_Sequence | KDYEEVGVDSVE |
| Peptide_Length | 12 |
| Peptide_SMILES | CC(C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1368.42 |
|---|---|
| Aliphatic_Index | 72.50000 |
| Aromaticity | 0.08333 |
| Average_Rotatable_Bonds | 3.83333 |
| Charge_at_pH_7 | -3.99694 |
| Isoelectric_Point | 3.63840 |
|---|---|
| Hydrogen_Bond_Acceptors | 21 |
| Hydrogen_Bond_Donors | 21 |
| Topological_Polar_Surface_Area | 636.40000 |
| X_logP_energy | -6.05610 |
Interaction Information
| Affinity | KD=100 uM |
|---|---|
| Affinity_Assay | Airfuge ultracentrifugation |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Differential interaction of synthetic peptides from the carboxyl-terminal regulatory domain of tubulin with microtubule-associated proteins |
| Release_Year | 1988 |
| PMID | 3416830 |
| DOI | 10.1002/j.1460-2075.1988.tb03033.x |