PPIRE17115

Target Protein Information
Protein_Name Microtubule-associated protein tau
Protein_Sequence MAEPRQEFDVMEDHAQGDYTLQDQEGDMDPGLKESPLQTPADDGSEEPGSETSDAKSTPTAEDATAPLVDEGAPGEQAAAQAPAEIPEGTAAEEAGIGDTSNLEDQAAGHVTQARMVSKGKDGTGPDDKKTKGADGKPGTKIATPRGAAPPGQKGQANATRIPAKTTPTPKTSPATMQVQKKPPPAGAKSERGESGKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSAAKSRLQAAPGPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Organism_Source Bos taurus
Functional_Classification microtubule associated proteins
Cellular_Localization Cytoplasm
Gene_Names MAPT
UniProt_ID P29172
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name beta(422-434)
Peptide_Sequence YQQYQDATADEQG
Peptide_Length 13
Peptide_SMILES C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1516.50
Aliphatic_Index 15.38462
Aromaticity 0.15385
Average_Rotatable_Bonds 3.76923
Charge_at_pH_7 -3.00105
Isoelectric_Point 3.38003
Hydrogen_Bond_Acceptors 24
Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 757.47000
X_logP_energy -9.95930
Interaction Information
Affinity KD=100 uM
Affinity_Assay equilibrium dialysis
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Differential interaction of synthetic peptides from the carboxyl-terminal regulatory domain of tubulin with microtubule-associated proteins
Release_Year 1988
PMID 3416830
DOI 10.1002/j.1460-2075.1988.tb03033.x