PPIRE17170

Target Protein Information
Protein_Name Tyrosine-protein phosphatase non-receptor type 6
Protein_Sequence MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
Organism_Source Homo sapiens
Functional_Classification protein tyrosine phosphatase
Cellular_Localization Cytoplasm
Gene_Names PTPN6
UniProt_ID P29350
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LKpYMQMF
Peptide_Sequence LKpYMQMF
Peptide_Length 8
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification Y3=phosphotyrosine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification biotin-ABBB
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1057.33
Aliphatic_Index 48.75000
Aromaticity 0.25000
Average_Rotatable_Bonds 4.12500
Charge_at_pH_7 0.99684
Isoelectric_Point 9.29830
Hydrogen_Bond_Acceptors 14
Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 347.57000
X_logP_energy 0.43590
Interaction Information
Affinity KD=2.4 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Determination of the Binding Specificity of the SH2 Domains of Protein Tyrosine Phosphatase SHP-1 through the Screening of a Combinatorial Phosphotyrosyl Peptide Library
Release_Year 2000
PMID 11052678
DOI 10.1021/bi0014397