PPIRE17176

Target Protein Information
Protein_Name Tyrosine-protein phosphatase non-receptor type 6
Protein_Sequence MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
Organism_Source Homo sapiens
Functional_Classification protein tyrosine phosphatase
Cellular_Localization Cytoplasm
Gene_Names PTPN6
UniProt_ID P29350
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LYpYANLI
Peptide_Sequence LYpYANLI
Peptide_Length 8
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(C)C)C(=O)O
Chemical_Modification Y3=phosphotyrosine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification biotin-ABBB
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 966.14
Aliphatic_Index 158.75000
Aromaticity 0.25000
Average_Rotatable_Bonds 3.25000
Charge_at_pH_7 -0.00372
Isoelectric_Point 6.08660
Hydrogen_Bond_Acceptors 12
Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 341.78000
X_logP_energy 0.22830
Interaction Information
Affinity KD=0.65 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Determination of the Binding Specificity of the SH2 Domains of Protein Tyrosine Phosphatase SHP-1 through the Screening of a Combinatorial Phosphotyrosyl Peptide Library
Release_Year 2000
PMID 11052678
DOI 10.1021/bi0014397