PPIRE17240
Target Protein Information
| Protein_Name | Ig gamma-1 chain C region secreted form/Immunoglobulin kappa constant |
|---|---|
| Protein_Sequence | AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMNTNGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK/RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
| Organism_Source | Mus musculus/Homo sapiens |
| Functional_Classification | immunoglobulins |
| Cellular_Localization | Extracellular |
| Gene_Names | Ighg1/IGKC |
| UniProt_ID | P01868/P01834 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | DDK |
|---|---|
| Peptide_Sequence | CDYKDDDDK |
| Peptide_Length | 9 |
| Peptide_SMILES | NCCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | ANP photocleavable linker |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1116.12 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.11111 |
| Average_Rotatable_Bonds | 4.22222 |
| Charge_at_pH_7 | -3.06320 |
| Isoelectric_Point | 3.85107 |
|---|---|
| Hydrogen_Bond_Acceptors | 19 |
| Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 554.89000 |
| X_logP_energy | -6.21370 |
Interaction Information
| Affinity | KD=1.01 nM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Label-free detection microarray for novel peptide Ligands screening base on MS-SPRi combination |
| Release_Year | 2014 |
| PMID | 25618725 |
| DOI | 10.1016/j.talanta.2014.12.012 |