PPIRE17250

Target Protein Information
Protein_Name Growth factor receptor-bound protein 7
Protein_Sequence MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
Organism_Source Homo sapiens
Functional_Classification SH2 domain containing proteins
Cellular_Localization Cytoplasm
Gene_Names GRB7
UniProt_ID Q14451
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name G7-M2
Peptide_Sequence CDNAXNATGAC
Peptide_Length 11
Peptide_SMILES C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CS)[C@@H](C)O)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification X5=carboxyphenylalanine
Cyclization_Method main chainide chain cyclization; N1<-->C11; thioether bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 996.03
Aliphatic_Index 27.27273
Aromaticity 0.00000
Average_Rotatable_Bonds 2.72727
Charge_at_pH_7 -1.12552
Isoelectric_Point 3.74996
Hydrogen_Bond_Acceptors 18
Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 498.03000
X_logP_energy -9.96530
Interaction Information
Affinity KD=2.1 uM
Affinity_Assay Isothermal Titration Calorimetry
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity
Release_Year 2019
PMID 31627265
DOI 10.3390/molecules24203739