PPIRE17274

Target Protein Information
Protein_Name HLA class II histocompatibility antigen DR beta 5 chain
Protein_Sequence MVCLKLPGGSYMAKLTVTLMVLSSPLALAGDTRPRFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTVQRRVEPKVTVYPARTQTLQHHNLLVCSVNGFYPGSIEVRWFRNSQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRAQSESAQSKMLSGVGGFVLGLLFLGAGLFIYFKNQKGHSGLHPTGLVS
Organism_Source Homo sapiens
Functional_Classification MHC class 2
Cellular_Localization Plasma membrane
Gene_Names HLA-DRB5
UniProt_ID Q30154
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DQw6(43-58)
Peptide_Sequence DVGVYRAVTPQGRPDA
Peptide_Length 16
Peptide_SMILES CC(C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification AMCA labeled
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1700.87
Aliphatic_Index 66.87500
Aromaticity 0.06250
Average_Rotatable_Bonds 3.12500
Charge_at_pH_7 -0.00198
Isoelectric_Point 6.44316
Hydrogen_Bond_Acceptors 24
Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 764.19000
X_logP_energy -8.97616
Interaction Information
Affinity KM=1300 nM
Affinity_Assay high performance size-exclusion chromatography
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM
Release_Year 1996
PMID 8790398
DOI 10.1073/pnas.93.18.9724