PPIRE17338
Target Protein Information
| Protein_Name | Platelet glycoprotein 4 |
|---|---|
| Protein_Sequence | MGCDRNCGLIAGAVIGAVLAVFGGILMPVGDLLIQKTIKKQVVLEEGTIAFKNWVKTGTEVYRQFWIFDVQNPQEVMMNSSNIQVKQRGPYTYRVRFLAKENVTQDAEDNTVSFLQPNGAIFEPSLSVGTEADNFTVLNLAVAAASHIYQNQFVQMILNSLINKSKSSMFQVRTLRELLWGYRDPFLSLVPYPVTTTVGLFYPYNNTADGVYKVFNGKDNISKVAIIDTYKGKRNLSYWESHCDMINGTDAASFPPFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRFVLPSKAFASPVENPDNYCFCTEKIISKNCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGLNPNEEEHRTYLDIEPITGFTLQFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETGTIGDEKANMFRSQVTGKINLLGLIEMILLSVGVVMFVAFMISYCACRSKTIK |
| Organism_Source | Homo sapiens |
| Functional_Classification | scavenger receptors |
| Cellular_Localization | Plasma membrane |
| Gene_Names | CD36 |
| UniProt_ID | P16671 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | EP80317 |
|---|---|
| Peptide_Sequence | XXkWfK |
| Peptide_Length | 6 |
| Peptide_SMILES | NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CN)C(=O)O |
| Chemical_Modification | X1=1-amino-cyclohexane-1-carboxylic acid; X2=2-methyltryptophan |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 721.86 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.33333 |
| Average_Rotatable_Bonds | 3.83333 |
| Charge_at_pH_7 | 1.99739 |
| Isoelectric_Point | 10.80538 |
|---|---|
| Hydrogen_Bond_Acceptors | 9 |
| Hydrogen_Bond_Donors | 10 |
| Topological_Polar_Surface_Area | 276.65000 |
| X_logP_energy | -0.69020 |
Interaction Information
| Affinity | KD=2.64 uM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Modified peptide monolayer binding His-tagged biomolecules for small ligand screening with SPR biosensors |
| Release_Year | 2011 |
| PMID | 21698315 |
| DOI | 10.1039/c1an15235a |