PPIRE17429

Target Protein Information
Protein_Name DNA repair protein RAD51 homolog 1
Protein_Sequence MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
Organism_Source Homo sapiens
Functional_Classification recombinases
Cellular_Localization Nucleus
Gene_Names RAD51
UniProt_ID Q06609
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P1
Peptide_Sequence FHTASGKKVKIAKESLDKVKNLFDE
Peptide_Length 25
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2833.28
Aliphatic_Index 78.00000
Aromaticity 0.08000
Average_Rotatable_Bonds 4.08000
Charge_at_pH_7 2.09157
Isoelectric_Point 10.11638
Hydrogen_Bond_Acceptors 41
Hydrogen_Bond_Donors 41
Topological_Polar_Surface_Area 1199.50000
X_logP_energy -10.70000
Interaction Information
Affinity KD=3.95 M
Affinity_Assay fluorescence spectroscopy
PDB_ID 1N0W
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Design synthesis and interaction of BRC4 analogous peptides with RAD51(24160)
Release_Year 2019
PMID 31875260
DOI 10.1007/s00726-019-02813-3