PPIRE17463

Target Protein Information
Protein_Name Speract receptor
Protein_Sequence MAHARHLFLFMVAFTITMVIARLDFNPTIINEDRGRTKIHVGLLAEWTTADGDQGTLGFPALGALPLAISLANQDSNILNGFDVQFEWVDTHCDINIGMHAVSDWWKRGFVGVIGPGCGCTYEGRLASALNIPMIDYVCDENPVSDKSIYPTFLRTIPPSIQVVEAIILTLQRYELDQVSVVVENITKYRNIFNTMKDKFDERDYEILHEEYYAGFDPWDYEMDDPFSEIIQRTKETTRIYVFFGDASDLRQFAMTALDEGILDSGDYVILGAVVDLEVRDSQDYHSLDYILDTSEYLNQINPDYARLFKNREYTRSDNDRALEALKSVIIVTGAPVLKTRNWDRFSTFVIDNALDAPFNGELELRAEIDFASVYMFDATMQLLEALDRTHAAGGDIYDGEEVVSTLLNSTYRSKTDTFYQFDENGDGVKPYVLLHLIPIPKGDGGATKDSLGMYPIGTFNRENGQWGFEEALDEDANVLKPVWHNRDEPPLDMPPCGFHGELCTNWALYLGASIPTFLIIFGGLIGFFIYRKRAYEAALDSLVWKVDWSEVQTKATDTNSQGFSMKNMVMSAISVISNAEKQQIFATIGTYRGTVCALHAVHKNHIDLTRAVRTELKIMRDMRHDNICPFIGACIDRPHISILMHYCAKGSLQDILENDDIKLDSMFLSSLIADLVKGIVYLHSSEIKSHGHLKSSNCVVDNRWVLQITDYGLNEFKKGQKQDVDLGDHAKLARQLWTSPEHLRQEGSMPTAGSPQGDIYSFAIILTELYSRQEPFHENEMDLADIIGRVKSGEVPPYRPILNAVNAAAPDCVLSAIRACWPEDPADRPNIMAVRTMLAPLQKGLKPNILDNMIAIMERYTNNLEELVDERTQELQKEKTKTEQLLHRMLPPSIASQLIKGIAVLPETFEMVSIFFSDIVGFTALSAASTPIQVVNLLNDLYTLFDAIISNYDVYKVETIGDAYMLVSGLPLRNGDRHAGQIASTAHHLLESVKGFIVPHKPEVFLKLRIGIHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGLALRIHVSPWCKQVLDKLGGYELEDRGLVPMNGKGEIHTFWLLGQDPSYKITKVKPPPQKLTQEAIEIAANRVIPDDV
Organism_Source Strongylocentrotus purpuratus
Functional_Classification guanylate cyclases
Cellular_Localization Plasma membrane
Gene_Names None
UniProt_ID P16065
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P15
Peptide_Sequence GQTQFGVCIARVRQQHQGQDESIFQAILSQCQS
Peptide_Length 33
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CN)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C8<-->C32; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3692.10
Aliphatic_Index 70.90909
Aromaticity 0.06061
Average_Rotatable_Bonds 3.84848
Charge_at_pH_7 -0.03284
Isoelectric_Point 7.25497
Hydrogen_Bond_Acceptors 54
Hydrogen_Bond_Donors 58
Topological_Polar_Surface_Area 1690.33000
X_logP_energy -22.73366
Interaction Information
Affinity KD=57 pM
Affinity_Assay equilibrium binding assay (centrifugation)
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title A 130-kDa Membrane Protein of Sperm Flagella Is the Receptor for Asterosaps Sperm-Activating Peptides of Starfish Asterias amurensis
Release_Year 2000
PMID 10677262
DOI 10.1006/dbio.1999.9598