PPIRE17482
Target Protein Information
| Protein_Name | Eukaryotic translation initiation factor 4E |
|---|---|
| Protein_Sequence | MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV |
| Organism_Source | Homo sapiens |
| Functional_Classification | eukaryotic initiation factors |
| Cellular_Localization | Cytoplasm |
| Gene_Names | EIF4E |
| UniProt_ID | P06730 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | eIF4GI peptide |
|---|---|
| Peptide_Sequence | KYTYDELFQLK |
| Peptide_Length | 11 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1447.65 |
|---|---|
| Aliphatic_Index | 70.90909 |
| Aromaticity | 0.27273 |
| Average_Rotatable_Bonds | 4.36364 |
| Charge_at_pH_7 | -0.00208 |
| Isoelectric_Point | 6.47966 |
|---|---|
| Hydrogen_Bond_Acceptors | 20 |
| Hydrogen_Bond_Donors | 20 |
| Topological_Polar_Surface_Area | 584.74000 |
| X_logP_energy | -2.27840 |
Interaction Information
| Affinity | KD=0.117 uM |
|---|---|
| Affinity_Assay | Isothermal Titration Calorimetry |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Rational Design and Biophysical Characterization of Thioredoxin-Based Aptamers: Insights into Peptide Grafting |
| Release_Year | 2010 |
| PMID | 19895821 |
| DOI | 10.1016/j.jmb.2009.10.069 |