PPIRE17505

Target Protein Information
Protein_Name Sex peptide receptor
Protein_Sequence MDNYTDVLYQYRLAPSASPEMEMELADPRQMVRGFHLPTNESQLEIPDYGNESLDYPNYQQMVGGPCRMEDNNISYWNLTCDSPLEYAMPLYGYCMPFLLIITIISNSLIVLVLSKKSMATPTNFVLMGMAICDMLTVIFPAPGLWYMYTFGNHYKPLHPVSMCLAYSIFNEIMPAMCHTISVWLTLALAVQRYIYVCHAPMARTWCTMPRVRRCTAYIALLAFLHQLPRFFDRTYMPLVIEWNGSPTEVCHLETSMWVHDYIGVDLYYTSYYLFRVLFVHLLPCIILVTLNILLFAAMRQAQERRKLLFRENRKKECKKLRETNCTTLMLIVVVSVFLLAEIPIAVVTAMHIVSSLIIEFLDYGLANICIMLTNFFLVFSYPINFGIYCGMSRQFRETFKEIFLGRLMAKKDSSTKYSIVNGARTCTNTNETVL
Organism_Source Drosophila melanogaster
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SPR
UniProt_ID Q8SWR3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MIP2
Peptide_Sequence AWKSMNVAWa
Peptide_Length 10
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1163.36
Aliphatic_Index 59.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 3.40000
Charge_at_pH_7 0.99769
Isoelectric_Point 9.70000
Hydrogen_Bond_Acceptors 15
Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 446.14000
X_logP_energy -2.32500
Interaction Information
Affinity EC50=23.4 nM
Affinity_Assay aequorin assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Myoinhibiting peptides are the ancestral ligands of the promiscuous Drosophila sex peptide receptor
Release_Year 2010
PMID 20458515
DOI 10.1007/s00018-010-0393-8