PPIRE17515

Target Protein Information
Protein_Name None
Protein_Sequence MAVTIDNSTNDFEFQKPFNYSINENITYFDYTNFTSDDFCASNNSHVYLNVTCEFAISYAEPMYGYIAPFLLATTTVANTLIVVVLSRRHMRTPTNAVLMAMALCDMFTMLFPAPWLFYMYTFGNHYKPLSPVRACQAWNYMNEVIPAMFHTASIWLTLALAVQRYIYVCHAPVARTWCTMPRVMKCLIYIGIAAFLHQLPRFFDRCYTPHKTVWRGRVEEVCRIEMASWVKALSVDAYFISYFGFRVLFVHLIPCTSLVVLNVLLFRAMRTAQINRQKLFKENRKSECKRLRDSNCTTLMLIVVVTVFLLVEIPVAVVTILHIISSTIVEILDYHIANILVLVTNFFIIVSYPINFAIYCGMSRQFRETFKELFIRGTVTSRKNGGSSRYSLVNGPRTCTNETVL
Organism_Source Bombyx mori
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SPR
UniProt_ID B0F4F1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MIP5
Peptide_Sequence XQAQGWNKFRGAWa
Peptide_Length 14
Peptide_SMILES C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CN)C(=O)O
Chemical_Modification X1=pyroglutamate
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification pyroglutamyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1576.74
Aliphatic_Index 21.42857
Aromaticity 0.21429
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 1.99769
Isoelectric_Point 11.65178
Hydrogen_Bond_Acceptors 20
Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 690.39000
X_logP_energy -6.85603
Interaction Information
Affinity EC50=4.6 nM
Affinity_Assay aequorin assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Myoinhibiting peptides are the ancestral ligands of the promiscuous Drosophila sex peptide receptor
Release_Year 2010
PMID 20458515
DOI 10.1007/s00018-010-0393-8