PPIRE17519

Target Protein Information
Protein_Name None
Protein_Sequence METDCFRNINVQEAILIQFNNFNVITKHTFAHLAVMTIILMANNIQKLENEAFYNLTNLKAVDLSKNKIRKLAPASIIGVSNRFLLTLNFNLIEKLDANFFIFGPIDHFSLELNDNKIIRIDPNAFTSIKAKKIECLYLGKNPLTELDDQVFENHTFGKIDLTGISFKVISSNLCKNCQIDYLLFDKFVLANWKFRYFLFYVLSSVNIKIYALNETQKFDLATDFEALHIVIEHENYPFLCNSLFNFSGKVIGTLFISQCNVVEIQKHIFRPFNVTESVEITFNRIPIIKSETFMDLAITNLLLSENQIELVEDNSFCNLHNLRMLHLNNNKIKRLNCLAFDNLPNLLNLYFTSNKIKKLPSNCLSFVERDNFMIDLSANKISSLEDNFWNDFGKQNLSLLLNDNLITTLPDGIFNYHTFNMLHLDSNPLTNISEHICYKNCTILQLLLDKEWLHGCDNFFELPISSNEIATKLRSSRNNSNKFNQSLFFITLFVFKY
Organism_Source Tribolium castaneum
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names GLEAN_15273
UniProt_ID D2A4Z5
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SP
Peptide_Sequence WEWPWNRKPTKFPIPSPNPRDKWCRLNLGPAWGGRC
Peptide_Length 36
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C24<-->C36; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4348.04
Aliphatic_Index 35.27778
Aromaticity 0.16667
Average_Rotatable_Bonds 3.47222
Charge_at_pH_7 4.87536
Isoelectric_Point 11.02498
Hydrogen_Bond_Acceptors 53
Hydrogen_Bond_Donors 59
Topological_Polar_Surface_Area 1669.23000
X_logP_energy -11.53672
Interaction Information
Affinity EC50=10.7 nM
Affinity_Assay aequorin assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Myoinhibiting peptides are the ancestral ligands of the promiscuous Drosophila sex peptide receptor
Release_Year 2010
PMID 20458515
DOI 10.1007/s00018-010-0393-8