PPIRE17622

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 1/Immunoglobulin lambda constant 1
Protein_Sequence ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA/GQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
Organism_Source Homo sapiens/Homo sapiens
Functional_Classification single chain variable fragment
Cellular_Localization Extracellular
Gene_Names IGHG1/IGLC1
UniProt_ID P01857/P0CG04
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name peptide 77
Peptide_Sequence AMFQDPQERPRC
Peptide_Length 12
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1477.68
Aliphatic_Index 8.33333
Aromaticity 0.08333
Average_Rotatable_Bonds 3.83333
Charge_at_pH_7 -0.06178
Isoelectric_Point 6.31801
Hydrogen_Bond_Acceptors 21
Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 650.42000
X_logP_energy -6.91396
Interaction Information
Affinity KD=0.39 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title A peptide-based fluorescent ratiometric sensor for quantitative detection of proteins
Release_Year 2010
PMID 20188691
DOI 10.1016/j.ab.2010.02.029