PPIRE17624
Target Protein Information
| Protein_Name | Immunoglobulin heavy constant gamma 1/Immunoglobulin lambda constant 1 |
|---|---|
| Protein_Sequence | ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA/GQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
| Organism_Source | Homo sapiens/Homo sapiens |
| Functional_Classification | single chain variable fragment |
| Cellular_Localization | Extracellular |
| Gene_Names | IGHG1/IGLC1 |
| UniProt_ID | P01857/P0CG04 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | peptide 47 |
|---|---|
| Peptide_Sequence | KRTAMFQDPQERPRC |
| Peptide_Length | 15 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1863.14 |
|---|---|
| Aliphatic_Index | 6.66667 |
| Aromaticity | 0.06667 |
| Average_Rotatable_Bonds | 4.06667 |
| Charge_at_pH_7 | 1.93793 |
| Isoelectric_Point | 9.82337 |
|---|---|
| Hydrogen_Bond_Acceptors | 27 |
| Hydrogen_Bond_Donors | 30 |
| Topological_Polar_Surface_Area | 845.87000 |
| X_logP_energy | -9.68649 |
Interaction Information
| Affinity | KD=0.21 nM |
|---|---|
| Affinity_Assay | Competition binding assay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | A peptide-based fluorescent ratiometric sensor for quantitative detection of proteins |
| Release_Year | 2010 |
| PMID | 20188691 |
| DOI | 10.1016/j.ab.2010.02.029 |