PPIRE17702

Target Protein Information
Protein_Name Proto-oncogene tyrosine-protein kinase LCK
Protein_Sequence MGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLVTYEGSLPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFFTATEGQYQPQP
Organism_Source Mus musculus
Functional_Classification tyrosine kinases
Cellular_Localization Cytoplasm
Gene_Names Lck
UniProt_ID P06240
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name EPQY*EEIPIYL
Peptide_Sequence EPQXEEIPIYL
Peptide_Length 11
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)O)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification X4=phosphotyrosine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1287.43
Aliphatic_Index 106.36364
Aromaticity 0.09091
Average_Rotatable_Bonds 3.54545
Charge_at_pH_7 -2.99754
Isoelectric_Point 3.47280
Hydrogen_Bond_Acceptors 17
Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 511.96000
X_logP_energy -2.16340
Interaction Information
Affinity KD=5.9 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Kinetic Analysis of the Mass Transport Limited Interaction between the Tyrosine Kinase lck SH2 Domain and a Phosphorylated Peptide Studied by a New Cuvette-Based Surface Plasmon Resonance Instrument
Release_Year 2000
PMID 10683231
DOI 10.1006/abio.1999.4464