PPIRE17710

Target Protein Information
Protein_Name T cell receptor alpha chain constant/T-cell receptor beta-2 chain C region
Protein_Sequence IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS/EDLRNVTPPKVSLFEPSKAEIANKQKATLVCLARGFFPDHVELSWWVNGKEVHSGVSTDPQAYKESNYSYCLSSRLRVSATFWHNPRNHFRCQVQFHGLSEEDKWPEGSPKPVTQNISAEAWGRADCGITSASYHQGVLSATILYEILLGKATLYAVLVSGLVLMAMVKKKNS
Organism_Source Homo sapiens/Mus musculus
Functional_Classification T cell receptors
Cellular_Localization Plasma membrane
Gene_Names TRAC/
UniProt_ID P01848/P01851
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Tax-Y5A
Peptide_Sequence LLFGAPVYV
Peptide_Length 9
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 978.20
Aliphatic_Index 162.22222
Aromaticity 0.22222
Average_Rotatable_Bonds 2.88889
Charge_at_pH_7 -0.00287
Isoelectric_Point 6.09320
Hydrogen_Bond_Acceptors 11
Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 307.56000
X_logP_energy 1.02940
Interaction Information
Affinity KD=33 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title T Cell Receptor Binding Transition States and Recognition of Peptide/MHC
Release_Year 2007
PMID 17249694
DOI 10.1021/bi061702p