PPIRE17795

Target Protein Information
Protein_Name Troponin C skeletal muscle
Protein_Sequence MASMTDQQAEARAFLSEEMIAEFKAAFDMFDADGGGDISTKELGTVMRMLGQNPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELANCFRIFDKNADGFIDIEELGEILRATGEHVTEEDIEDLMKDSDKNNDGRIDFDEFLKMMEGVQ
Organism_Source Gallus gallus
Functional_Classification EF hand calcium binding proteins
Cellular_Localization Cytoplasm
Gene_Names TNNC2
UniProt_ID P02588
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Rp40
Peptide_Sequence GDEEKRNRAITARRQHLKSVMLQIAATELEKEEGRREAEK
Peptide_Length 40
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)CN)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)[C@@H](C)CC)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4678.26
Aliphatic_Index 68.50000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.30000
Charge_at_pH_7 1.10234
Isoelectric_Point 9.36811
Hydrogen_Bond_Acceptors 68
Hydrogen_Bond_Donors 79
Topological_Polar_Surface_Area 2228.04000
X_logP_energy -25.07778
Interaction Information
Affinity KD=2 uM
Affinity_Assay NMR chemical shift perturbation
PDB_ID 1JC2
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Structure Dynamics and Thermodynamics of the Structural Domain of Troponin C in Complex with the Regulatory Peptide 1-40 of Troponin I
Release_Year 2001
PMID 11513585
DOI 10.1021/bi010748+