PPIRE17843
Target Protein Information
| Protein_Name | Phospholipase A2 membrane associated |
|---|---|
| Protein_Sequence | MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC |
| Organism_Source | Homo sapiens |
| Functional_Classification | phospholipase A2 |
| Cellular_Localization | Extracellular |
| Gene_Names | PLA2G2A |
| UniProt_ID | P14555 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | c(2NapA)LS(2NapA)R |
|---|---|
| Peptide_Sequence | XLSXR |
| Peptide_Length | 5 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)O |
| Chemical_Modification | X1=2-naphthylalanine; X4=2-naphthylalanine |
| Cyclization_Method | Main chain-main chain cyclization; X1<-->R5; amide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 488.54 |
|---|---|
| Aliphatic_Index | 78.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.20000 |
| Charge_at_pH_7 | 0.99798 |
| Isoelectric_Point | 10.55000 |
|---|---|
| Hydrogen_Bond_Acceptors | 8 |
| Hydrogen_Bond_Donors | 10 |
| Topological_Polar_Surface_Area | 261.85000 |
| X_logP_energy | -4.09803 |
Interaction Information
| Affinity | IC50=12.8 uM |
|---|---|
| Affinity_Assay | E. coli membrane assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | A Novel Approach to the Design of Inhibitors of Human Secreted Phospholipase A2 Based on Native Peptide Inhibition |
| Release_Year | 2001 |
| PMID | 11427527 |
| DOI | 10.1074/jbc.M101272200 |