PPIRE17847

Target Protein Information
Protein_Name Troponin C skeletal muscle
Protein_Sequence MASMTDQQAEARAFLSEEMIAEFKAAFDMFDADGGGDISTKELGTVMRMLGQNPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELANCFRIFDKNADGFIDIEELGEILRATGEHVTEEDIEDLMKDSDKNNDGRIDFDEFLKMMEGVQ
Organism_Source Gallus gallus
Functional_Classification EF hand calcium binding proteins
Cellular_Localization Cytoplasm
Gene_Names TNNC2
UniProt_ID P02588
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TnI115-131
Peptide_Sequence RMSADAMLKALLGSKHK
Peptide_Length 17
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1857.26
Aliphatic_Index 86.47059
Aromaticity 0.00000
Average_Rotatable_Bonds 3.94118
Charge_at_pH_7 3.08845
Isoelectric_Point 11.07954
Hydrogen_Bond_Acceptors 28
Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 775.32000
X_logP_energy -7.43393
Interaction Information
Affinity KD=24 uM
Affinity_Assay binding assay
PDB_ID 1NPQ
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title NMR Structure of a Bifunctional Rhodamine Labeled N-Domain of Troponin C Complexed with the Regulatory witchPeptide from Troponin I: Implications for in Situ Fluorescence Studies in Muscle Fibers
Release_Year 2003
PMID 12693929
DOI 10.1021/bi027041n