PPIRE17918

Target Protein Information
Protein_Name Melanocortin receptor 5
Protein_Sequence MNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNKHLVIADTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIWTFCISCGIVFIIYYESKYVIICLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRTSMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNVYCSCFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIVCCHGFRRPCRLLGGY
Organism_Source Mus musculus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Mc5r
UniProt_ID P41149
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AMW3-130
Peptide_Sequence YCHfRWNAPHCY
Peptide_Length 12
Peptide_SMILES C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C2<-->C10; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1596.80
Aliphatic_Index 8.33333
Aromaticity 0.33333
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 1.05415
Isoelectric_Point 8.23721
Hydrogen_Bond_Acceptors 21
Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 593.23000
X_logP_energy -2.94963
Interaction Information
Affinity EC50=2.3 nM
Affinity_Assay cAMP-based Beta-galactosidase reporter gene assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Incorporation of a Bioactive Reverse-Turn Heterocycle into a Peptide Template Using Solid-Phase Synthesis To Probe Melanocortin Receptor Selectivity and Ligand Conformations by 2D 1H NMR
Release_Year 2011
PMID 21306168
DOI 10.1021/jm101425m