PPIRE18037

Target Protein Information
Protein_Name None
Protein_Sequence MSFLFSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTESTCSVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDAVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR
Organism_Source Xenopus laevis
Functional_Classification protein kinase regulatory subunits
Cellular_Localization Cytoplasm
Gene_Names mob1a.L
UniProt_ID Q7T1M9
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name XlNDR68-86
Peptide_Sequence AHARKETEFLRLKRTRLGLW
Peptide_Length 20
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2481.93
Aliphatic_Index 88.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 4.25000
Charge_at_pH_7 4.09184
Isoelectric_Point 12.07913
Hydrogen_Bond_Acceptors 32
Hydrogen_Bond_Donors 41
Topological_Polar_Surface_Area 1075.39000
X_logP_energy -7.80012
Interaction Information
Affinity KD=100 nM
Affinity_Assay NMR chemical shift perturbation
PDB_ID 1R3B
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title NMR Solution Structure of Mob1 a Mitotic Exit Network Protein and its Interaction with an NDR Kinase Peptide
Release_Year 2004
PMID 15001360
DOI 10.1016/j.jmb.2004.01.010